Effect of Vitamin B2 and Vitamin E on Cancer-Related Sarcopenia in a Mouse Cachexia Model

Cancer-related sarcopenia is associated with impaired energy metabolism and increased oxidative stress production in skeletal muscles. With an aim to treat cancer-related using dietary intervention, we investigated the effects of vitamin B2 (VB2) E (VE), which are recognized have antioxidant effects, on CT26 mouse colon cancer cells muscles vitro vivo. VB2 suppressed tumor growth by suppressing cell proliferation inducing more pronounced apoptosis increasing adenosine triphosphate (ATP) reactive oxygen species (ROS). VE decreasing ATP ROS. In C2C12 myoblast cells, treatment ROS decreased ROS; both treatments maturation. model, intraperitoneal inoculation (peritoneal model) resulted marked macrophage infiltration elevated blood necrosis factor-α high-mobility group box-1 inflammatory cytokine levels, leading cachexia. contrast, subcutaneous (subcutaneous showed poor low without activated macrophages exacerbated peritoneal whereas did not exhibit significant changes model. order improve it important consider effect cytokines.